Pop Sci AAV 4UPop 4USci Guide History Aug 11, 2026 20:03

Stochastic Model Dynamics✕

Maximum-Entropy Model of Colored Noise in Superdiffusive Axonal Growth arxiv.org
Correcting hidden sampling biases in null models of canalizing Boolean networks arxiv.org
Stochastic partial differential equation model for environmental DNA dynamics in river environments arxiv.org
Permutation theory governs long-term dynamics of critical Boolean networks arxiv.org
Algebraic formulas for first-passage times of Markov processes in the linear framework: generalising the work of Hill and Kac arxiv.org
Approximate Analytical Protein Distributions for the Three-stage Model of Stochastic Gene Expression arxiv.org
Inferring disruption of directed graphs using LIKA reveals altered protein phosphorylation networks in schizophrenia biorxiv.org

Multimodal Data Analysis✕

BMDS-Net:Deployment-aware multi-modal brain tumor segmentation with adaptive fusion,decoder regularization,and Bayesian calibration arxiv.org
Uncertainty-Aware Missing-Data Multimodal Latent for Fetal-Growth Analysis arxiv.org
Predicting blood clot growth from sparse post-onset measurements with latent neural differential equations arxiv.org
$\texttt{DisMorph}$: learning to disentangle technical distortions from true biological change arxiv.org
Flow-based conditional cardiac anatomy generation for virtual cohorts arxiv.org
A generative model for dimensionality reduction with millions of features and few samples biorxiv.org

Cancer Resistance Strategies✕

TRAPS: Treatment-Assignment Prediction via Pathway-informed Stratification arxiv.org
Hit Selection Using SSMD-Based Machine Learning Performance Metrics in High-Throughput Screening Assays arxiv.org
Cross-study analysis identifies estrogen depletion and exposure duration as key determinants of bisphenol A transcriptomic potency in MCF-7 cells. Toxicology reports
pysigscore: gene signatures scoring across bulk and single-cell transcriptomics biorxiv.org
Identifying multi-omics biomarkers for ovarian cancer survival estimation biorxiv.org
rAAV production cost analysis: Indication-specific cost per dose and reduction strategies nature.com
From RAS inhibitor resistance to rational combination strategies nature.com
Acquired resistance to the RAS(ON) multi-selective inhibitor daraxonrasib guides rational combination therapy strategies in pancreatic cancer nature.com

Spatial Multiomics Development✕

Loom: Multi-Region Analysis of Spatial Transcriptomics with Local Neighborhoods and Global Trajectories arxiv.org
Virtual spatial transcriptomics from histopathology enables prognostic and therapeutic response prediction in cancer biorxiv.org
FOCUS: end-to-end preprocessing, alignment and resolution-matched integration of spatial multi-omics data biorxiv.org
A Principled Statistical Framework for Analyzing Spatial Patterns in Spatially Resolved Multi-Omics biorxiv.org
Whole-transcriptome-scale isoform-resolved spatial imaging of single cells in tissues cell.com
Spatial proximity sequencing maps developmental dynamics in the germinal center cell.com
A spatial snapshot of hair follicle development nature.com

Biological Sequence Modeling✕

Evolutionary Curriculum Learning Improves Biological Sequence Modeling arxiv.org
Idea Search: Guiding Tree Search with Ideas to Explore Diverse Scientific Methods arxiv.org
Distribution-Constrained Optimization for Reliable ML-Guided 5'UTR Sequence Design biorxiv.org
Agentic genomics: From pipeline automation to autonomous validation cell.com
Why machines don’t speak biology: Toward native biological language models cell.com
AI-assisted design of synthetic gene editors nature.com
Thinking and rethinking data AI readiness nature.com

Protein Interaction Quantification✕

Experimental access to molarity's blind spot in macroscopic assays arxiv.org
A concentration-independent paradigm rendering weak interactions inherently quantifiable arxiv.org
Exploiting chemical shift variability enables recovery of overlapping metabolites from 1H nuclear magnetic resonance spectra arxiv.org
A General Theory for Phenotypic Association in Biological Systems arxiv.org
Scalable Extraction of Information on Protein-Protein Interactions using Topological Data Analysis biorxiv.org
PandaMap: A Python Package for Comprehensive Visualization of Protein-Ligand Interaction Networks biorxiv.org
Dynamic dimer-of-dimers architecture defines Mg2+ transport in human CNNM4 cell.com

Single Cell Embedding✕

JUMP-lite: Compact, reproducible benchmarking of cell representations arxiv.org
scYeast: a biological-knowledge-guided foundation model on yeast single-cell transcriptomics. Synthetic and systems biotechnology
Move BeTween modAlities (MBTA) employs flow matching to predict single cell data modalities biorxiv.org
Universal cell embedding for single-cell biology nature.com

Tumor Microenvironment Immunotherapy✕

Single-cell and longitudinal transcriptomics-guided engineering of FZD1-targeting precision nanotherapy against osteosarcoma cancer stem cells. Bioactive materials
Integrative single-cell and spatial transcriptomic approaches to decipher the tumor microenvironment and therapeutic resistance in pancreatic cancer. Cancer biology & therapy
Exploratory multi-omics links CCL2/TIMP1 axis to immunosuppressive TME in glioblastoma. Cell cycle (Georgetown, Tex.)
POU2F2 as a dual oncogenic and immunomodulatory driver in kidney renal clear cell carcinoma. Cell adhesion & migration
Characterization of persistent HPV-specific activated T cells in head and neck squamous cell carcinoma. Oncoimmunology
Cancer associated fibroblast-T cell crosstalk promotes purinergic synthesis in non-small cell lung cancer (NSCLC). Oncoimmunology
scXpand: Pan-cancer detection of T cell clonal expansion from single-cell RNA sequencing without paired single-cell TCR sequencing cell.com
The critical role of the endogenous immune compartment after CAR T cell therapy in recurrent GBM cell.com
Cuproptosis-immunity crosstalk informs strategy to overcome immunotherapy resistance cell.com
Localized PD-1 CAR T therapy reprograms neuroinflammation cell.com
Targeting peripheral 5-HT2AR enhances antitumor immunity in colorectal cancer cell.com
Spatial biology reveals altered macrophage states in immunosuppressed non-melanoma skin cancer cell.com
Neutrophil extracellular traps promote liver metastasis by impairing NK cell-dependent tumor surveillance via CCDC25 nature.com

Genomic Sequencing Analysis✕

Comparative genomics and phenotypes of Listeria monocytogenes isolated from enoki mushrooms in South Korea and China. Food microbiology
Dual β-lactam therapy against high-risk Pseudomonas aeruginosa isolates: a dynamic in-vitro infection model study integrating population genomics with quantitative systems pharmacology modelling and simulations. The Lancet. Microbe
Disruption of rcnB modulates colistin susceptibility in Acinetobacter baumannii AB5075. Virulence
A novel Acinetobacter phage reveals altered virulence traits in phage-resistant strains. Virulence
Population genomics reveals a long-term increase in azole resistance associated with the emerging cluster AZR among Candida tropicalis causing invasive infections. Emerging microbes & infections
Verification of nanopore sequencing technology for clinical carbapenem-resistant Enterobacterales surveillance biorxiv.org
Mandatory use of mock communities highlighted by the descriptive comparison of Epi2Me 16S and EMU bioinformatic workflows for full-length 16S rRNA Nanopore sequencing. biorxiv.org
Pooled amplicon sequencing for characterizing mutations in the praziquantel molecular target TRPMPZQ in schistosome populations from Western Kenya biorxiv.org
PanGBank: a large-scale resource of precomputed microbial pangenomes built with PPanGGOLiN biorxiv.org
SeqDesk: a sequencing-facility management system for standards-compliant and FAIR (meta)data submission biorxiv.org
Phylogenomics and comparative genomics of the genus Erwinia reveal taxonomic inconsistencies and evolutionary diversification biorxiv.org
Genomic plasticity and homologous recombination drive the evolution of Pectobacterium jejuense across hosts and geographic regions biorxiv.org
orthoSynAssign: refine orthogroups using synteny information biorxiv.org
Targeted genomic editing of human gut Bacteroides species based on CRISPR-associated transposases cell.com

Disease Immune Mechanisms✕

An integrated approach combining transcriptomics, network pharmacology, and experimental validation are used to investigate the mechanism of Lonicerae Japonicae Flos and Forsythiae Fructus extracts against acute lung injury in chickens. Journal of ethnopharmacology
Taohe Chengqi Decoction ameliorates APID-related local uterine inflammatory injury through modulation of inflammation, oxidative stress, and JNK/p38 MAPK-NF-κB-related signaling. Journal of ethnopharmacology
Investigating and validating the molecular mechanisms of lipid metabolism regulation in myasthenia gravis development based on single-cell, bulk transcriptomics, and RT-qPCR. Autoimmunity
From signals to systems: the epigenetic-microbiome-mitochondrial axis in IBD pathogenesis. Gut microbes
Is Fusobacterium nucleatum the key mediator between oral infections and systemic diseases? Mechanistic insights and therapeutic implications. Gut microbes
Immune regulatory mechanisms and potential microbiota-associated targets in Kawasaki disease: an integrative multi-omics and network pharmacology study. Artificial cells, nanomedicine, and biotechnology
Paternal Metabolic Reversal Remodels Sperm RNA Profiles and Ameliorates Intergenerational Metabolic Disorder in Mice biorxiv.org
Intrauterine growth restriction is associated with adaptive hematopoietic reprogramming and selective immune rewiring in monozygotic twins biorxiv.org
Dietary arginine drives codon-dependent MHC class I translation and improves immunity in colon tumorigenesis and respiratory viral infection cell.com
Milk osteopontin alters the infant microbiome to drive DC hematopoiesis and disease tolerance cell.com
Gene augmentation therapy successfully treats mice with complete congenital stationary night blindness (cCSNB), improving retinal function and visual acuity nature.com
A gene therapy approach to prevent dilated intercellular space, a hallmark of gastroesophageal reflux disease nature.com
Drug self-administration in head-fixed mice nature.com

Tissue Regeneration Development✕

Sheep in vivo models for evaluation of safety, functionality and regenerative potential of arterial grafts. MethodsX
From neural development to regenerative medicine: A research journey in stem cell biology, spinal cord repair, and iPSC-based drug discovery. Regenerative therapy
Human heart valve-like tissues from pluripotent stem cells with enhanced maturation recapitulate inflammatory valve disease cell.com
Human iPSC-derived heart valve-like assembloids model valve development and disease pathology cell.com
A Linc1405/Eomes Complex Promotes Cardiac Mesoderm Specification and Cardiogenesis cell.com
Reconstituting human primitive streak formation through extra-embryonic cell coordination cell.com
Multiscale integration of tissue and chromatin context converts cell heterogeneity into stable intestinal patterning cell.com
Recurrent patterns of TOP1-mediated neuronal genomic damage shared by major neurodegenerative disorders cell.com
The intrinsic cardiac nervous system is essential for cardiac function and survival cell.com
Distinct cellular phenotypes of language and executive decline in amyotrophic lateral sclerosis cell.com
Breathing new life into the rational design of Alzheimer’s therapeutics cell.com
A flexible repertoire of wound closure strategies precedes whole-body regeneration nature.com
Plasticity of human microglia and brain perivascular macrophages in aging and Alzheimer’s disease nature.com

Zoonotic Disease Risk✕

Parahenipavirus langyaense (Langya virus): Spillover ecology, noncanonical receptor-mediated entry, and future control strategies. One health (Amsterdam, Netherlands)
Genotype-specific ecological and environmental drivers of HPAI H5N1 spread in wild birds in France, 2021-2023 biorxiv.org
Detection of diverse coronaviruses, paramyxoviruses, and rhabdoviruses from cave-dwelling bats in Eastern Uganda biorxiv.org
Inference of nodavirus zoonotic transmission networks from publicly available sequencing data biorxiv.org
Emergence of a Bundibugyo virus variant in the 2026 outbreak in the Democratic Republic of the Congo and Uganda nature.com

Biotech News Synthesis✕

From Wikipedia to AI: Measuring 25 years of synthesis of human genetics research in the public-facing information ecosystem biorxiv.org
Biotech news from around the world nature.com
Tech giants plunge into life sciences nature.com

Aging Genetic Interactions✕

Not all tumors age alike: Bidirectional epigenetic age shifts across 20 solid tumors biorxiv.org
DetectGxT: detecting gene-by-treatment interactions on molecular count phenotypes accounting for allelic additivity biorxiv.org
Using summary data to detect and quantify ascertainment in biobanks biorxiv.org
Genetic drivers of protein changes over time: Findings, considerations, and approaches in TOPMed cohorts and UK Biobank biorxiv.org
A Pseudo-Longitudinal Methylome Projection Framework Defines a Buccal PACE-like Aging-Rate Score from Cross-Sectional DNA Methylation Data biorxiv.org
Uncovering High-Order Epistatic Interactions in GWAS via a Machine Learning-Based Feature Engineering Framework biorxiv.org
Genome-wide association study in Heterogeneous Stock rats identifies genetic loci associated with aversion-based learning and cocaine aversion biorxiv.org
Polygenic risk scores and plasma proteomics identify cancer-related proteins and trans-regulated protein networks cell.com
Trans-regulatory gene mapping prioritizes disease drivers in asthma cell.com
Anti-aging interventions need less hype and more clinical evidence nature.com

Genome Population Analysis✕

A red-eye mutant in Nesidiocoris tenuis (Hemiptera: Miridae) is caused by exon skipping due to an indel mutation in the scarlet gene biorxiv.org
A chromosome-level genome of the franciscana dolphin, Pontoporia blainvillei biorxiv.org
A Unified Deep Learning-Based Framework for Reference-Based and Reference-Free Local Ancestry Inference biorxiv.org
eRREMS expands regulatory CpG coverage in reduced representation methylome sequencing biorxiv.org
BLink-seq delivers population-scale haplotypes without long reads: a scalable framework for non-model genomics biorxiv.org
Discovery and characterization of highly polymorphic ultra-short STRs for human identification via shotgun sequencing biorxiv.org
pbcftools: parallel execution of bcftools for large variant call sets biorxiv.org
A comparative genomics framework for identifying historical population bottlenecks using olfactory receptor gene evolution biorxiv.org
Ancient DNA reveals matrilineal organisation and recurrent unions between dominant matrilines in Iron Age Britain biorxiv.org
Microhaplotypes Improve Kinship Estimation in Heterozygous, Mixed-Ploidy Populations of Actinidia biorxiv.org
The Pan-European Impact of the Balkan Hunter-Gatherers biorxiv.org
Multiple chromosomal inversions shape the genetic structure of a commercial bivalve biorxiv.org
Finishing a complete giraffe genome from telomere to telomere with Verkko-Fillet cell.com
Telomere-to-telomere genome assembly and a pangenome for the rat cell.com
On the ancestry and evolution of the extinct dire wolf cell.com
Phased T2T horse and donkey assemblies from a mule reveal peculiar equid centromere evolution cell.com
Automatic generation of model sequences for complex regions in assembly graphs with TTT cell.com

Cell Disease Pathophysiology✕

Locus-specific transposable element expression drives human hematopoietic stem cell disease pathophysiology biorxiv.org
Characterization of the frameshift c.515dupC knock-in mouse model of HSPB8-associated myopathy (MFM13) and evaluation of Trehalose as autophagy modulating therapy. biorxiv.org
Programmed Clonal Expansion Drives an ATM-Dependent Vulnerability Underlying Preferential Lymphocyte Depletion and Myeloid Bias Following DNA Damage biorxiv.org
The mitochondria enzyme OGDH defends against disulfidptosis by licensing METTL3-regulated NRF2 translation nature.com

Chromatin Gene Regulation✕

Cohesin promotes genomic stability by suppressing unequal sister chromatid exchange biorxiv.org
Cohesin loading at regulatory elements shapes 3D genome folding during erythropoiesis biorxiv.org
Mapping genome-wide RNA-RNA and RNA-DNA interactions in nuclear hubs of male and female Drosophila cells biorxiv.org
Depletion of lamin-associated polypeptide 2alpha leads to chromatin reorganization and binding of A-type lamins to open genomic regions biorxiv.org
Auto-sumoylation of UBC9 coordinates meiotic prophase and protects ovarian reserves biorxiv.org
Systematic investigation reveals extensive Epstein-Barr virus transcriptional regulation of the human genome cell.com
Chromatin topology and distal elements underlie divergent cell-type-specific regulation of 9p21 locus cell cycle genes cell.com
Haplotype-resolved DiMeLo-seq maps centromeric chromatin in a complete diploid human genome cell.com
Robust regulatory interplay of enhancers, facilitators, and promoters in a native chromatin context cell.com
Condensates of the chromatin regulator ANKRD11 restrict hypertranscribed genes to safeguard development cell.com
Mega-enhancers compartmentalize transcriptionally active long genes in the brain nature.com
A chromatin remodeller silences SINE retrotransposons nature.com
Histone marks are conserved across eukaryotes but chromatin states are diversified nature.com

Small RNA DNA Editing✕

PUS7 mRNA pseudouridylation is driven by RNA sequence, structure, and cell-type-specific features cell.com
Precision correction of the <i>GJB2</i> c.235delC mutation by prime editing in vitro nature.com
Author Correction: HERD-1 mediates multiphase condensate immiscibility to regulate small RNA-driven transgenerational epigenetic inheritance nature.com
Light up your space with glowing houseplants nature.com
Prime prevails in Beam dispute nature.com
Overestimations in the cyclization efficiency of small, restriction enzyme-digested DNA fragments nature.com
Reply to: Overestimations in the cyclization efficiency of small, restriction enzyme-digested DNA fragments nature.com

Imaging Cell Dynamics✕

Glycoform engineering of a mammalian platform to sculpt a humanized recombinant bioscavenger cell.com
An optogenetic smart microscopy platform reveals signaling dynamics-dependent control over collective cell migration cell.com
Advanced imaging of membrane contact sites nature.com
Magnetic microrobots for gastrointestinal drug delivery nature.com

Material Stability Synthesis✕

Boron-bridged GIPCs stabilize cell wall anchoring and PIN polar domains cell.com
Moiré-induced modulation of out-of-plane elasticity in twisted hBN nature.com
Iron-derived solid redox system for effective and sustainable sulfur recovery from sulfide-bearing wastewater nature.com
Origin of circular and triangular pores in electron-irradiated hexagonal boron nitride nature.com
Bromide-mediated paired electrosynthesis of hydrogen and epoxide nature.com
Overcoming the conversion-selectivity trade-off in plasma catalytic conversion of methane to ethylene nature.com
Healing intervention for improving the efficiency and stability of tandem devices on industrial textured silicon nature.com
Direct printing of metasurfaces using formulated optical materials nature.com
A general approach for the synthesis of nanoisland catalysts nature.com
Reusability report: Exploring the utility and extensibility of an integrated modelling framework for liquid electrolyte design nature.com

Human Brain Genomics Ai✕

Hierarchical and context-dependent encoding of actions in human posterior parietal and motor cortex cell.com
Early human crosstalk nature.com
AI-based multimodal integration of genomics and electronic health records nature.com
Lessons from deploying the ChatEHR system at Stanford Medicine nature.com
Capable language models can outgrow the benefits of collaboration nature.com
Beyond representational alignment with brain-guided language models for robust reasoning nature.com

Nat Med✕

Reinventing health communication for the digital era nature.com
Editorial Expression of Concern: CDK4 coexpression with Ras generates malignant human epidermal tumorigenesis nature.com
Global access to different classes of diabetes medicines: a framework for targeted policy actions nature.com

Nat Mach Intel✕

Impact-resistant, autonomous robots inspired by tensegrity architecture nature.com
Trajectory forecasting lifts the femtosecond ceiling in molecular simulation nature.com
Reinforcement learning steers generative crystal design nature.com
Classifying multipartite continuous-variable entanglement structures through data-augmented neural networks nature.com

Arxiv Genetics✕

Range wide analysis of genetic diversity and structure gives insights into Rosa gallica L. evolutionary history biorxiv.org
Telomere variant sequences encode the genetic blueprint for allele-specific telomere length biorxiv.org
Genetic mapping and genomic prediction for agronomic, grain compositional, and sensing-enabled traits in a cowpea MAGIC population along an environmental gradient biorxiv.org
Genetic mapping of a spontaneous short-grain mutation reveals a novel loss-of-function allele of SRS3 in rice biorxiv.org
Development of the First Cytochrome Oxidase I Barcode and Evidence for a Single Haplotype Associated with the Recent United States Invasion of the Pasture Mealybug Heliococcus summervillei (Pseudococcidae, Hemiptera) biorxiv.org
Flywheel Genomics: Simultaneous trait discovery and genetic gain in plant breeding biorxiv.org
Multi-environment GWAS analysis for photosynthetic light use efficiency in Arabidopsis thaliana biorxiv.org
MMMAS: A Mendelian Mismatch Matrix Analysis System for Deterministic Pre-Screening of Germplasm Collections biorxiv.org
Genetic and epigenetic divergence among Arabidopsis thaliana Col-0 laboratory lineages since the 1950s biorxiv.org
Repurposing the TIGR-Tas system for programmable transcription activation biorxiv.org
Identifying the causal allele in the CD40 autoimmune locus enables discovery of context-specific trans-effects in B cells biorxiv.org
Non-Invasive Embryo Quality Assessment via Matrix-Optimized Untargeted LC-MS Metabolomics of Spent Embryo Culture Media and Weighted Ensemble Machine Learning biorxiv.org
Genome-wide analysis reveals the importance of histone acetyltransferase Esa1 in transcriptional regulation during nitrogen starvation biorxiv.org

Arxiv Genomics✕

A genome-wide CRISPR activation map of surface protein expression in human CD4 T cells biorxiv.org
Quantitative profiling of intrinsic dCas9-DNA recognition reveals key determinants of guide RNA performance biorxiv.org
A pangenome-graph approach for mapping and imputing barley sequences biorxiv.org
Allelic Diversity and Core Conservation of Type III Effectors Across Xanthomonads Causing Bacterial Spot of Pepper and Tomato biorxiv.org
ABC1K7: A 350-Myr chloroplast rheostat fine-tuned during coconut domestication biorxiv.org
Comparative Transcriptome Analysis Unveils Mechanisms of Salt Tolerance in Bluebunch Wheatgrass biorxiv.org
Comparative Population Genomics across Three Continents Reveals Immune Adaptation and Implications for Vaccine Development biorxiv.org
Chloroplast Genome Evolution, Heteroplasmy, and Inverted Repeat Dynamics in the Elymus Complex (Triticeae, Poaceae): Insights from Single-Molecule Sequencing of Elymus ciliaris and Comparative Analysis of St-Genome Lineages biorxiv.org
Chromosome-scale Juglans genomes focus fungal defense gene divergence in gene presence and absence instead of copy number biorxiv.org
Cis-regulatory variation and transcription factor binding contribute to allelic genotype-by-environment interactions for gene expression in maize biorxiv.org
Mutational consequences of perturbing DNA repair and chromatin state in Arabidopsis biorxiv.org

Nat Gen✕

Prevalence and chronology of colibactin-associated mutational processes and their microbiome spectra in Japanese colorectal cancer nature.com
Epigenetic heterogeneity in AML nature.com
Cellular atlas of endocrine signaling nature.com
High-resolution promoter interaction analysis implicates genes involved in activation of type 3 innate lymphoid cells in immune disease risk nature.com

Cell Sys✕

Quantifying protein unfolding kinetics with a high-throughput microfluidic platform cell.com
Dynamic condensates enhance the robustness of biological oscillation cell.com
Delineation of signaling microdomains from live-cell movies cell.com
Foundation model reveals the shared organization of transcription and topologically associating domains cell.com
Evaluating SARS-CoV-2 antibody resilience via prediction and design of escape viral variants cell.com
Single-cell heterogeneity in interferon induction potential is heritable and governed by variation in cell state cell.com
Multimolecular proofreading overcomes the activity-fidelity trade-off cell.com
High-throughput DNA engineering by mating bacteria cell.com
Living bacterial reservoir computers for information processing and sensing cell.com
A data-driven modeling framework for mapping genotypes to synthetic microbial community functions cell.com
Scalable enumeration and sampling of minimal metabolic pathways for organisms and communities cell.com
Deciphering protein mutation-phenotype linkages from CRISPR-based tiling mutagenesis screens cell.com
Integrated control of redox and energy metabolism by the membrane-bound and soluble transhydrogenases of Pseudomonas putida across metabolic regimes cell.com
High-throughput machine learning-aided antibody discovery for cell surface antigens cell.com
Pooled combinatorial screening identifies transcription factor sets that drive hematopoietic progenitor-like cell fate cell.com
Discovering what is possible: How synthetic biology illuminates development cell.com

Arxiv Qbio✕

MAPK Pathway Activity and Heme Biosynthesis Gene Expression in IDH-Wildtype Glioblastoma: A Purity-Adjusted, Discovery-Validation Analysis arxiv.org
VOICE: A Vision-Omics Foundation Model Integrating Direct and Retrieval-Based Prediction of In-situ Single-Cell Gene Expression arxiv.org
Local growth laws determine global shape of molluscan shells arxiv.org

Cell Genomics✕

PlantCAD2: A DNA foundation model for interpreting genomes across flowering plants cell.com
Base editing for precision therapeutics cell.com
Are different populations fairly represented in single-cell omic atlases? cell.com
Compound delivery of eVLPs enhances prime editing for targeted genome engineering and high-throughput screening cell.com

Europepmc Genomics✕

Engineering short-sequence elements for condensate-like assemblies by de novo design. Synthetic and systems biotechnology
Live-attenuated Toxoplasma gondii RHΔddx6 mutant establishes comprehensive immunity against acute, chronic, and congenital toxoplasmosis. Virulence
VPS33A and VPS18 orchestrate porcine epidemic diarrhea virus replication by modulating autophagic flux. Virulence
Cross-host transmission of Riemerella anatipestifer to chickens: Genomic evolution and identification of the novel vapX-like-vapD toxin-antitoxin system. Virulence
Recent advances of CRISPR-based gene editing technologies and delivery strategies. Artificial cells, nanomedicine, and biotechnology
CRISPR/Cas9-mediated knockout of MsMLO1 confers enhanced powdery mildew resistance in alfalfa. aBIOTECH
Multifaceted effects of galU deletion on phenotype and virulence of Pseudomonas aeruginosa in vitro and in vivo. Virulence
Vaccine diluent affects expression levels of immune related genes in caecal tonsils of layer chickens vaccinated with live attenuated Salmonella Typhimurium vaccine. The veterinary quarterly
Multi-omics integration deciphers arsenic-induced multi-organ toxicity and the novel ferroptosis axis. Toxicology reports
Interactive effects of temperature and water activity on growth, mycotoxin production, and transcriptomic profiles of Aspergillus flavus, Aspergillus parasiticus, and Fusarium verticillioides. Food microbiology
Cross-feeding and stress response are the basis of increased fruitiness and leavening capacity of a new consortium of the sourdough microorganisms Companilactobacillus crustorum and Wickerhamomyces anomalus. Food microbiology
Multi-omics profiling identifies CDK1 as a key mediator of mitosis through the PTN pathway in bladder cancer. Future science OA
iNOS/NO-Induced autophagy primes PANoptosis as the central driver of streptococcal toxic shock-like syndrome in zoonotic Streptococcus suis infection. Emerging microbes & infections
Sensitive detection of prostate cancer antigen 3 (PCA3) in urine based upon CRISPR/Cas12a and gold nanorods (AuNRs). Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
Reprogramming macrophage mechanosensation via TRPV4 modulating mechano-immunotherapy controls fibrotic encapsulation of biomaterial implants. Bioactive materials
Versatile hollow Ca2+-phenolic nanoparticles for intracellular delivery of diverse bioactive molecules and CRISPR-Cas9 genome editing. Biomaterials
Jasmonate, salicylate, and ethylene-responsive transcriptomics discovery in spikelets of three wheat genotypes reveals a rapid and conserved response for jasmonate signaling. Plant signaling & behavior
Advances in SEC61G research: from ER translocon subunit to emerging pan-cancer oncogenic roles. Cancer biology & therapy

Cell✕

Reshaping Antibody Diversity cell.com
Pangenome-guided breeding restores high-altitude adaptation and improves yield in Tartary buckwheat cell.com
Convergent evolution of metabolic regulation governs redox adaptation in Toxoplasma cell.com
The sex and reproductive plasticity of intestinal muscles instruct gut size cell.com
The structural basis for LRRK2’s activation and autoinhibition cell.com
Structure-based design of non-hypertrophic apelin receptor modulator cell.com
Metabolic atlas of early human cortex reveals glycolytic remodeling and pentose phosphate pathway control of cell fate transitions cell.com
Ultrarapid deep 3D histology enables intraoperative mapping of glioma infiltration cell.com
Co-option of retrotransposons promotes antibody diversification cell.com
Spatial atlas of the human brain vasculature reveals specialized cell ensembles cell.com
Basement membrane turnover controls cell shape cell.com
CRISPR screens identify targets to rescue age-related T cell dysfunction in cancer cell.com
Gasdermin E couples viral pyroptosis to lethal hepatic lipid accumulation cell.com
Advancing cancer detection and treatment using longitudinal routine clinical data cell.com
An Oryza orphan gene confers trans-species drought tolerance cell.com
Trichoderma swollenin activates AtABCB5-dependent auxin efflux to promote plant development cell.com
A domestication-selected enhancer coordinates source-sink balance to improve harvest index and yield in maize cell.com
CSF clearance through arachnoid fenestrations to olfactory meningeal lymphatics cell.com
A bivalent molecular glue linking lysine acetyltransferases to oncogene-induced cell death cell.com
Viral protease-initiated lytic cell death as a universal antiviral mRNA therapy cell.com
Skin-innervating glutamatergic neurons modulate aging cell.com
A viral ORFeome library for systems-level genetic dissection of host-pathogen interactions cell.com
Four-dimensional molecular mapping from a spatial snapshot reveals the dynamics of hair follicle organogenesis cell.com
Co-option of lysosomal machinery shapes the evolution of the intracellular photosymbiosis supporting coral reefs cell.com
Systematic discovery of pathogen effector functions across human pathogens and pathways cell.com
Structural basis for host membrane binding and remodeling by invading malaria parasites cell.com
Excessive epithelial mechanosensation drives nociceptive innervation and chronic bladder pain via the PIEZO1-SLC7A11-glutamate axis cell.com
Geometric constraints on the architecture of mammalian cortical connectomes cell.com
Expansion and CAR engineering of granulocyte-monocyte progenitors for cellular immunotherapy cell.com
Chloroplast sunscreening by protein condensates confers high-light tolerance cell.com
Complete biosynthesis of the anticancer cephalotaxinone and homoerythratine cell.com
Prion-based protein self-assembly tunes mutagenesis to enable rapid adaptation cell.com

Arxiv Bfx✕

Virtual-cell verification enables self-auditing AI discovery for immune rejuvenation biorxiv.org
What Makes a Good Vaccine Antigen Target? Defining Key Features and Predicting Candidates in the Staphylococcus aureus Proteome biorxiv.org
nf-cavalier: A Nextflow Pipeline for Rare Disease Variant Prioritization and Reporting biorxiv.org
A Framework for Benchmarking Pathway Reconstruction Algorithms biorxiv.org
A map of human protein-protein interaction embeddings for functional discovery biorxiv.org
A distribution-aware and functionally relevant novel framework for generation and discovery of bioactive peptides biorxiv.org
Scop3P-Toolkit: executable structure-aware workflows linking PTMs, peptides, and mutations to protein function biorxiv.org
Elucidating biosynthetic pathways related to the synthesis of small halogenated peptidic natural products in marine sponge microbiomes biorxiv.org
Assessing Computational Models for Pharmacogenomic Variant Interpretation biorxiv.org
De novo transformer modeling improves recovery of genetic cell types from sparse single-cell RNA sequencing biorxiv.org
DigiAra Computationally Designs Plant Mutants for Resistance to Microbial Infection in Arabidopsis biorxiv.org
A hierarchical orthology framework reveals viral carbohydrate-active genes across the global virosphere biorxiv.org
Phylogeny-aided detection of contamination in nearly 5 million SARS-CoV-2 genomes biorxiv.org
HANSEN: An Integrated Structural and Functional Proteome Resource for Structure-Guided Drug Discovery in Mycobacterium leprae biorxiv.org

Nat Rev Gen✕

Genetics and genomics of hybridization nature.com
The genetics of complex gene expression phenotypes illuminated nature.com
Embracing non-linearity in human ageing nature.com
Towards quantifying immune diversity through HLA genomics nature.com
Bidirectional functional genomics using CRISPR-KOALA nature.com
Genomic, epigenomic and transcriptomic regulation of cellular senescence nature.com
Human genetics across levels of biological organization nature.com

Nature Cellbio✕

PGAM1 rheostat in glycolysis and autophagy nature.com
Targeting oncogenic FLT3 uncovers a ferroptosis vulnerability through selenocysteine recoding in acute myeloid leukaemia nature.com

Nature Biotech✕

Killing resistant tumors with a click nature.com
Microbiomics nature.com

Nat Protocols✕

ONE microscopy nature.com
Standardized assays for evaluating superoxide dismutase-like and catalase-like activities of nanozymes nature.com
Three-dimensional tracking of dynamic structures in living cells using single-plane imaging with focus feedback nature.com

Cell Stem✕

TIGRa: An ultra-compact programmable activator enabling multiplexed and efficient gene regulation cell.com

Gene Therapy✕

An engineered helper plasmid generates differential E4orf6 and L4-22/33K gene expression increasing AAV vector production nature.com
SACF and GILA for in vitro transformation assessment of CRISPR/Cas9-edited cell therapy candidates: a multi-site study nature.com
Bone- and muscle-targeted adeno-associated viral vectors enable tissue-selective vitamin D receptor knockdown in mice nature.com
Reversing cancer cell behavior using AI-guided CRISPR and quantum nanobiology: a systems-based approach to epigenetic reprogramming nature.com